Evaluating the anti Mycobacterium tuberculosis activity of Alpinia galanga (L.) Willd. axenically under reducing oxygen conditions and in intracellular assays

Table 1 Characteristics of strains used for testing the antimycobacterial activity of A . galanga

Sr. no	Strain ID	Drug susceptibility profile*	rpoβ ^Ψ genotype	katG ^Ψ genotype	inhA promoter genotype
1	H37Rv	Susceptible	Wild type	Wild type	Wild type
2	S1	Susceptible	Wild type	Wild type	Wild type
3	S2	Susceptible	Wild type	Wild type	Wild type
4	S3	Susceptible	Wild type	Wild type	Wild type
5	R1	Resistant to HR	D516V mixed	S315T1/T2	A16G mixed
6	R2	Resistant to HERZ	D516V mixed	S315T1/T2	A16G mixed
7	R3	Resistant to HERZ	S531L	S315T1/T2 mixed	Wild type

Antimycobacterial activity of A.galanga under anaerobic conditions was tested using only H37Rv.
H-isoniazid, E-Ethambutol, R-Rifampicin, Z-Pyrazinamide.
S- Drug susceptible strain.
R- Drug resistant strain.
*Phenotypic drug resistance was ascertained using the BACTEC MGIT 960 system.
^ΨGenotypic drug resistance was ascertained using the GenoType MTBDRplus assay (Hain Lifescience, Germany). Mixed indicates heteroresistance (presence of wild type and mutant bands).

ISSN: 2662-7671