Table 2 Antinociceptive effect of C. rotundus extract and morphine in tail immersion test
From: Evaluation of antinociceptive activity of hydromethanol extract of Cyperus rotundus in mice
Treatment | Dose (mg/kg) | Response time (s) (%MPE) | ||||
|---|---|---|---|---|---|---|
Pretreatment | 30 min | 60 min | 90 min | 120 min | ||
Vehicle | 0.1 ml/mice | 2.83 ± 0.48 | 2.62 ± 0.37 | 2.68 ± 0.46 | 2.66 ± 0.43 | 2.59 ± 0.48 |
Morphine sulphate | 5 | 2.66 ± 0.56 | 5.42 ± 0.47**(37.62) | 6.21 ± 0.41**(48.32) | 4.64 ± 0.31*(26.00) | 3.57 ± 0.40(12.45) |
HMCR | 50 | 2.31 ± 0.37 | 3.25 ± 0.47(12.22) | 3.98 ± 0.17(21.71) | 3.14 ± 0.12(10.87) | 2.62 ± 0.24(4.03) |
HMCR | 100 | 2.66 ± 0.12 | 3.66 ± 0.35(13.61) | 4.52 ± 0.32*(25.33) | 3.88 ± 0.34*(16.61) | 2.97 ± 0.17(4.30) |
HMCR | 200 | 2.54 ± 0.49 | 3.87 ± 0.35(17.88) | 4.44 ± 0.36*(25.47) | 4.16 ± 0.34*(21.66) | 3.14 ± 0.24(8.04) |