Table 1 Antinociceptive effect of C. rotundus extract and morphine in hot plate test
From: Evaluation of antinociceptive activity of hydromethanol extract of Cyperus rotundus in mice
Treatment | Dose (mg/kg) | Response time (s) (%MPE) | ||||
|---|---|---|---|---|---|---|
Pretreatment | 30 min | 60 min | 90 min | 120 min | ||
Vehicle | 0.1 ml/mice | 7.44 ± 0.48 | 7.89 ± 0.62 | 7.52 ± 0.86 | 7.91 ± 0.90 | 8.44 ± 0.83 |
Morphine sulphate | 5 | 8.70 ± 0.72 | 14.89 ± 1.01**(54.72) | 18.17 ± 0.66**(83.76) | 14.70 ± 0.26**(53.04) | 12.99 ± 0.93(37.94) |
HMCR | 50 | 8.22 ± 0.91 | 10.27 ± 0.55(17.45) | 11.97 ± 0.28*(31.89) | 10.85 ± 0.90(22.35) | 9.22 ± 1.32(8.52) |
HMCR | 100 | 6.19 ± 0.91 | 10.11 ± 0.72(28.38) | 13.03 ± 1.18**(49.55) | 11.63 ± 0.97*(39.43) | 10.77 ± 0.83(33.17) |
HMCR | 200 | 8.22 ± 0.72 | 12.21 ± 0.62*(33.89) | 13.93 ± 0.63**(48.51) | 11.99 ± 0.76*(32.04) | 11.07 ± 1.47(24.19) |