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Table 4 Rectal temperature, weight and packed cell volume of infected animals treated with crude extract of Croton macrostachys in the Rane’s test

From: In vivo antimalarial activity of the crude leaf extract and solvent fractions of Croton macrostachyus Hocsht. (Euphorbiaceae) against Plasmodium berghei in mice

Animal group

T0

T4

% change

W0

W4

% change

PCV0

PCV4

% change

CON

37.4±0.14

36.6±0.05

−2.2

26.2±0.21

22.1±0.43

−7.7

54±0.31

53±0.21

−4.9

CM200

37.3±0.08

37.2±0.08

−0.2a2

26.3±0.11

25±0.16

−3.1a1

53±0.31

52±0.40

−1.9

CM400

37.4±0.09

37.4±0.04

0.0a3

26.4±0.11

26.3±0.05

−1.1a3

52.5±0.43

53±0.22

0.9

CM600

37.3±0.09

37.4±0.03

0.2a3

26.6±0.06

25.9±0.05

−1.8a2

52±0.31

53±0.44

1.9

CQ25

37.4±0.18

37.3±0.13

−0.2a2

26.5±0.04

25.9±0.04

−2.3a2

52.5±0.42

53±0.21

2.4

  1. Data are expressed as mean ± SEM; n = 6; a,compared to controls, 1p<0.05, 2p< 0.01, 3p< 0.001; CM, crude extract of Croton macrostachys; W, weight; T, temperature; PCV, packed cell volume; 0 refers at day 0 and 4 to day 4. Numbers refer to dose in mg/kg.