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Table 3 Parasitaemia and survival of infected animals treated with crude extract and chloroform fraction of Croton macrostachys in the Rane’s test

From: In vivo antimalarial activity of the crude leaf extract and solvent fractions of Croton macrostachyus Hocsht. (Euphorbiaceae) against Plasmodium berghei in mice

Extract Group Day 3 Day 4 Day 5 Day 6 Day 7 % inhibition Survival date
Crude extract CON 9±0.15 16±0.13 14±0.23 31±0.61 36±1.1 - 6±0.31
CM200 12±0.36 28±1.20 26±0.32 25±0.16 22±0.19 39a3,b3,c3 7±0.31b3,c3
CM400 11±0.43 19±0.95 16±0.85 14±0.54 11±0.95 69a3,c1 12±0.47a3,b3,c3
CM600 10±0.32 14±0.56 11±0.47 8±0.41 7±0.78 83a3 16±0.42a3,c3
CQ25 11±0.22 5±0.09 2±0.56 0 0.00±0.00 100a3 30±0a3
Chloroform fraction CON 21.8±0.58 26.6±0.90 33.1±0.81 40.7±0.67 54.6±1.34 - 7.2±0.31
CF200 20.8±0.83 20.8±0.66 20.2±0.92 19.8±0.50 18.5±0.63 66.2a3,c3 7.5±0.34c3
CF400 22.7±0.63 21.2±0.51 17.4±0.45 15.4±0.49 13.5±0.80 75.3a3,c3,e2 10.3±0.76a2,d3
CF600 21.8±0.79 20.9±0.62 15.4±1.02 11.5±0.45 9.7±0.65 82.3a3,c3,d1,e3 12.3±0.72a3,c3,e3
  CQ25 20.8±0.85 15.6±1.02 5.5±0.28 1.5±0.29 0.00±0.0 100a3 30.0±0.0a3
  1. Data are expressed as mean ± SEM; n = 6: a, compared to control; b, to 600 mg/kg; c, to CQ 25; d, to 400 mg/kg; e, to 200 mg/kg: 1p<0.05, 2p<0.01, 3p<0.001; CF = Chloroform fraction, CQ = chloroquine, MF, methanol fraction, AF, aqueous fraction, CON = Control, CM, crude extract of Croton macrostachys. Numbers refer to dose in mg/kg.