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Table 2 Temperature, weight and packed cell volume of infected animals treated with crude extract and solvent fractions of Croton macrostachys in the 4 day suppressive test

From: In vivo antimalarial activity of the crude leaf extract and solvent fractions of Croton macrostachyus Hocsht. (Euphorbiaceae) against Plasmodium berghei in mice

Extract

Animal group

Temperature

Weight

Packed cell volume

  

D0

D4

% change

D0

D4

% change

D0

D4

% change

Crude extract

CON

37.2±0.19

37.2±0.19

−2

26.0±0.18

24.0±0.43

−15.5

55±0.33

53±0.26

−3.6

CM200

37.5±0.08

37.2±0.07

−0.8a2

26.1±0.12

25.3±0.34

−5.2a1

53±1.34

53±1.48

0.0

CM400

37.1±0.11

37.1±0.11

0.5a2

26.2±0.11

25.9±0.15

−0.6a3

54±0.50

55±0.70

1.8

CM600

37.0±0.15

37.0±0.15

1.3a3

26.2±0.17

25.7±0.22

−2.8a2

54±0.55

56±0.84

3.5

CQ25

37.2±0.08

37.2±0.08

0.2a2

26.1±0.09

25.5±0.05

−2.4a2

53±0.55

55±0.42

3.8

Chloroform fraction

CON

37.3±0.42

32.9±0.21

−11.76

27.9±0.82

26.8±1.15

−4.00

53.3±1.46

49.7±1.61

−6.73

CF200

36.9±0.37

36.3±0.47

−1.59a3

27.17±0.64

25.15±1.16

−7.43b3

51.7±1.78

51.1±1.1

−1.14a1

CF400

37.5±0.32

37.4±0.23

−0.48a3

27.7±1.16

26.8±1.08

−3.82b2

52.2±1.25

52.2±1.16

0.00a2

CF600

37.7±0.49

37.4±0.39

−0.93a3

28.1±1.20

27.9±1.12

−0.89b1

51.7±1.82

53.3±1.90

3.23a3

CQ25

37.4±0.27

37.5±0.26

0.32a3

26.7±0.51

27.3±0.83

2.36a2

53.2±0.48

53.9±0.62

1.35a2

Methanol fraction

CON

37.3±0.21

35.4±0.17

−5.15

31.6±0.47

30.3±0.89

−3.83

53.8±1.61

52.3±1.05

−2.80

MF200

37.7±0.29

35.2±0.71

−6.63b3

26.6±0.47

27.2±0.54

2.44a3

53.2±0.98

50.4±0.70

−5.17b3

MF400

37.9±0.36

34.4±0.48

−9.24b3

26.8±0.55

28.1±0.59

4.43a3

52.8±0.96

51.2±0.90

−3.00b2

MF600

38.0±0.15

34.7±0.23

−8.73b3

28.1±0.89

29.4±0.81

4.52a3

50.9±1.28

51.1±1.47

0.25

CQ25

36.9±0.25

37.2±0.60

0.68a3

30.1±0.93

30.5±0.83

1.33a2

54.8±1.16

55.7±0.98

1.68a1

Aqueous fraction

CON

37.7±0.13

34.2±0.28

−9.30

31.7±0.57

30.4±0.65

−3.94

55.8±1.17

53.9±1.25

−3.40

AF200

37.1±0.46

34.9±0.32

−5.90b2

30.8±0.79

30.7±0.54

−0.39b1

56.8±0.96

55.3±0.54

−2.64b1

AF400

36.7±0.25

34.9±0.27

−5.20b2

29.2±0.86

28.9±0.75

−1.04b1

54.4±1.85

54.2±0.21

−0.46

AF600

36.6±0.35

34.9±0.56

−4.97b2

30.0±1.04

29.0±0.90

−3.26b2

56.4±1.14

55.8±0.77

−1.19b1

 

CQ25

36.9±0.35

36.6±0.26

−1.00a3

28.1±1.08

28.8±1.18

2.56a2

55.5±0.79

56.1±0.55

1.04a1

  1. Data are expressed as mean ± SEM; n = 6; a = compared to control, b = to chloroquine 25 mg/kg; 1p< 0.05; 2p<0.01, 3p<0.001; D0 = pre-treatment value on day 0, D4 = post-treatment value on day four, CF = Chloroform fraction, CQ = chloroquine, MF, methanol fraction, AF, aqueous fraction, CON = Control, CM, crude extract of Croton macrostachys. Numbers refer to dose in mg/kg.