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Table 2 Temperature, weight and packed cell volume of infected animals treated with crude extract and solvent fractions of Croton macrostachys in the 4 day suppressive test

From: In vivo antimalarial activity of the crude leaf extract and solvent fractions of Croton macrostachyus Hocsht. (Euphorbiaceae) against Plasmodium berghei in mice

Extract Animal group Temperature Weight Packed cell volume
   D0 D4 % change D0 D4 % change D0 D4 % change
Crude extract CON 37.2±0.19 37.2±0.19 −2 26.0±0.18 24.0±0.43 −15.5 55±0.33 53±0.26 −3.6
CM200 37.5±0.08 37.2±0.07 −0.8a2 26.1±0.12 25.3±0.34 −5.2a1 53±1.34 53±1.48 0.0
CM400 37.1±0.11 37.1±0.11 0.5a2 26.2±0.11 25.9±0.15 −0.6a3 54±0.50 55±0.70 1.8
CM600 37.0±0.15 37.0±0.15 1.3a3 26.2±0.17 25.7±0.22 −2.8a2 54±0.55 56±0.84 3.5
CQ25 37.2±0.08 37.2±0.08 0.2a2 26.1±0.09 25.5±0.05 −2.4a2 53±0.55 55±0.42 3.8
Chloroform fraction CON 37.3±0.42 32.9±0.21 −11.76 27.9±0.82 26.8±1.15 −4.00 53.3±1.46 49.7±1.61 −6.73
CF200 36.9±0.37 36.3±0.47 −1.59a3 27.17±0.64 25.15±1.16 −7.43b3 51.7±1.78 51.1±1.1 −1.14a1
CF400 37.5±0.32 37.4±0.23 −0.48a3 27.7±1.16 26.8±1.08 −3.82b2 52.2±1.25 52.2±1.16 0.00a2
CF600 37.7±0.49 37.4±0.39 −0.93a3 28.1±1.20 27.9±1.12 −0.89b1 51.7±1.82 53.3±1.90 3.23a3
CQ25 37.4±0.27 37.5±0.26 0.32a3 26.7±0.51 27.3±0.83 2.36a2 53.2±0.48 53.9±0.62 1.35a2
Methanol fraction CON 37.3±0.21 35.4±0.17 −5.15 31.6±0.47 30.3±0.89 −3.83 53.8±1.61 52.3±1.05 −2.80
MF200 37.7±0.29 35.2±0.71 −6.63b3 26.6±0.47 27.2±0.54 2.44a3 53.2±0.98 50.4±0.70 −5.17b3
MF400 37.9±0.36 34.4±0.48 −9.24b3 26.8±0.55 28.1±0.59 4.43a3 52.8±0.96 51.2±0.90 −3.00b2
MF600 38.0±0.15 34.7±0.23 −8.73b3 28.1±0.89 29.4±0.81 4.52a3 50.9±1.28 51.1±1.47 0.25
CQ25 36.9±0.25 37.2±0.60 0.68a3 30.1±0.93 30.5±0.83 1.33a2 54.8±1.16 55.7±0.98 1.68a1
Aqueous fraction CON 37.7±0.13 34.2±0.28 −9.30 31.7±0.57 30.4±0.65 −3.94 55.8±1.17 53.9±1.25 −3.40
AF200 37.1±0.46 34.9±0.32 −5.90b2 30.8±0.79 30.7±0.54 −0.39b1 56.8±0.96 55.3±0.54 −2.64b1
AF400 36.7±0.25 34.9±0.27 −5.20b2 29.2±0.86 28.9±0.75 −1.04b1 54.4±1.85 54.2±0.21 −0.46
AF600 36.6±0.35 34.9±0.56 −4.97b2 30.0±1.04 29.0±0.90 −3.26b2 56.4±1.14 55.8±0.77 −1.19b1
  CQ25 36.9±0.35 36.6±0.26 −1.00a3 28.1±1.08 28.8±1.18 2.56a2 55.5±0.79 56.1±0.55 1.04a1
  1. Data are expressed as mean ± SEM; n = 6; a = compared to control, b = to chloroquine 25 mg/kg; 1p< 0.05; 2p<0.01, 3p<0.001; D0 = pre-treatment value on day 0, D4 = post-treatment value on day four, CF = Chloroform fraction, CQ = chloroquine, MF, methanol fraction, AF, aqueous fraction, CON = Control, CM, crude extract of Croton macrostachys. Numbers refer to dose in mg/kg.