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Table 3 Effect of Paederia foetida Linn. on antioxidant marker in STZ-induced diabetic rats

From: Paederia foetida Linn. leaf extract: an antihyperlipidemic, antihyperglycaemic and antioxidant activity

S. No.

Biochemical parameter

Normal control

Normal control + PF (500 mg/kg)

STZ-Diabetic control

STZ diabetes + PF I (100 mg/kg)

STZ diabetes + PF II (250 mg/kg)

STZ diabetes + PF III (500 mg/kg)

STZ diabetes + Glibenclamide (10 mg/kg)

1

SOD (U/mg of protein)

7.8 ± 0.374

7.6 ± 0.245

2.2 ± .374a

4.2 ± 0.374b

5.2 ± 0.374b

7 ± 0.316b

6.6 ± 0.245b

2

CAT (U/mg of protein)

72 ± 1.612

70.6 ± 1.72

38 ± 1.732a

45.8 ± 1.068b

53.8 ± 1.158b

68 ± 1b

65.4 ± 1.077b

3

GPx (nmole/mg of protein)

32.8 ± 1.02

32.6 ± 1.208

13.2 ± 0.374a

19 ± 0.707b

24.6 ± 0.509b

31 ± 0.458b

29.6 ± 0.927b

4

MDA (nmole/mg of protein)

0.2 ± 0.011

0.21 ± 0.007

0.54 ± 0.013a

0.39 ± 0.009b

0.32 ± 0.005b

0.25 ± 0.005b

0.26 ± 0.003b

  1. Values are given as mean ± S.E.M. of six rats in each group. a(P <0.01) compared with the corresponding value for normal control animals (group I); b(P <0.01) compared with the corresponding value for diabetic control animals (group III); ns-non significant.