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Table 1 Significantly enriched KEGG biological pathways among top 0.1% candidate target-genes of DQP compositive compounds

From: DanQi Pill protects against heart failure through the arachidonic acid metabolism pathway by attenuating different cyclooxygenases and leukotrienes B4

KEGG pathway ID and name

P-valuea

Coverage (%)b

Path:hsa04080 Neuroactive ligand-receptor interaction

2.66E-07

6.29

Path:hsa04020 calcium signaling pathway

5.22E-06

7.30

Path:hsa04614 renin-angiotensin system

5.64E-06

9.41

Path:hsa00970 aminoacyl-tRNA biosynthesis

4.67E-05

14.63

Path:hsa00250 alanine, aspartate and glutamate metabolism

1.29E-04

16.13

Path:hsa00590 arachidonic acid metabolism

2.46E-03

18.62

Path:hsa00330 arginine and proline metabolism

1.15E-02

7.41

  1. aA pathway is significantly enriched with candidate target-genes when its corresponding upper-tailed P-value of hypergeometric cumulative distribution is smaller than 0.05. The pathways are ranked according to the order of the increasing P-values. bThe coverage for each pathway is referred to as the fraction of candidate target-genes among all the pathway member genes.