Subacute administration of crude khat (Catha edulis F.) extract induces mild to moderate nephrotoxicity in rats

Table 3 Effects of khat extract on activity of renal antioxidant enzymes and levels of malondialdehyde in rats

Groups	SOD (U/mg protein)	CAT (U/mg protein)	MDA (nmol/mg protein)
CON	259.50 ± 7.56	17.69 ± 0.73	2.60 ± 0.04
K100	249.49 ± 11.49	17.62 ± 0.56	2.86 ± 0.07
K200	240.66 ± 6.97	16.20 ± 0.40	3.68 ± 0.17^a1
K400	221.17 ± 7.51^a2	11.50 ± 0.87^a3	5.30 ± 0.16^a2
GEN	136.43 ± 4.94^a3b3c3d3	6.54 ± 0.47 ^a3b3c3d3	6.27 ± 0.19^a3b3c3d3

Values are mean ± SEM. n = 8; ^acompared to CON; ^bcompared to K100; ^ccompared to K200; ^dcompared to K400. ¹p < 0.05; ²p < 0.01; ³p < 0.001. (CON: control, received Tween80; K100, khat 100 mg/kg; K200, khat 200 mg/kg; K400, khat 400 mg/kg; GEN, gentamicin 100 mg/kg; SOD, superoxide dismutase; CAT, catalase; MDA, malondialdehyde).

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