Figure 7

Schematic diagram. COE inhibits the IL-1β and TNF-α-induced migration and invasion signal pathway in FLSs. COE blocks IL-1β and TNF-α-induced phosphorylation and degradation of IκBα, which inhibits the nuclear translocation of p65. This further suppresses the activation of NF-κB, and, thus, decreases MMP-9 expression and the subsequent migration and invasion of FLSs.