Antihypertensive potential of the aqueous extract which combine leaf of Persea americana Mill. (Lauraceae), stems and leaf of Cymbopogon citratus (D.C) Stapf. (Poaceae), fruits of Citrus medical L. (Rutaceae) as well as honey in ethanol and sucrose experimental model

Table 1 Effects of the extract on body weight gain, blood pressure and heart rate

	Body weight gain (g)	DAP (mm Hg)	MAP (mm Hg)	SAP (mm Hg)	HR (BPM)
Water	76.20 ± 1.98	76.92 ± 1.40	90.46 ± 1.29	117.50 ± 1.27	352.60 ± 3.77
Ethanol	79.95 ± 3.68	96.90 ± 1.38^aα	114.50 ± 1.67^aα	149.70 ± 2.46^aα	398.40 ± 2.06^aα
Sucrose	59.17 ± 1.91	98.48 ± 1 .40^aα	116.50 ± 1.78^aα	152.72 ± 2.67^aα	392.00 ± 3.52^aα
EtOH+ Su	52.02 ± 1.79	109.08 ± 1.29^a	129.70 ± 0.99^a	171.12 ± 2.71 ^a	423.80 ± 2.37^a
EtOH + Su + Nif	51.42 ± 2.31	90.68 ± 1.54^aα	106.00 ± 1.41^aα	136.70 ± 1.37^aα	372.60 ± 2.30^aα
EtOH + Su + Ext50	67.57 ± 2.62	80.92 ± 1.36^α	94.44 ± 1.39^α	121.48 ± 1.66^α	360.80 ± 1.95^α
EtOH + Su + Ext100	59.40 ± 2.03	77.50 ± 1.14^α	89.84 ± 1.05^α	114.54 ± 1.9^α	350.60 ± 1.88^α
EtOH + Su + Ext150	60.02 ± 1.53	76.94 ± 1.55^α	88.81 ± 1.52^α	112.56 ± 1.74^α	352.80 ± 3.01^α

Each value represents a mean ± S.E.M.; n = 5; ^ap < 0.001: significantly different compared to water. ^αp < 0.001: significantly different compared to ethanol and sucrose. DAP = diastolic arterial blood pressure, MAP = mean arterial blood pressure, SAP = systolic arterial blood pressure, HR = heart rate, EtOH + Su = Ethanol and Sucrose; Ext50, Ext100 and Ext150 = Extract at the respective doses of 50, 100 and 150 mg/kg; Nif = Nifedipine (10 mg/kg).

ISSN: 2662-7671