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Table 2 The top 30 down-regulated proteins in PAC treated P. aeruginosa bacteria

From: Cranberry proanthocyanidins have anti-biofilm properties against Pseudomonas aeruginosa

Downregulated

Proteins

Functional annotation

Accession number

Average spectra count

   

Untreated

Treated

ABC transporter PA4502

Peptide/nickel export system

15599698

13.7

0

hypothetical protein PA2481

ATP synthesis

15597677

8

0

DNA topoisomerase I TopA

Repair system

15598207

7.7

0

homogentisate 1,2-dioxygenase HmgA

Aromatic amino acid metabolism

15597205

16.3

0.1

4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase GcpE

Terpenoid backbone biosynthesis

15598998

11.3

0.1

inosine 5′-monophosphate dehydrogenase GuaB

Purine metabolism

15598965

6.7

0.1

preprotein translocase subunit SecA

Bacterial secretion system

15599599

6.7

0.1

hypothetical protein PA5545

Protein processing

15600738

6.7

0.1

adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA

Cofactor and vitamin synthesis

15595617

6.3

0.1

hypothetical protein PA2765

Unknown function

15597961

6.3

0.1

3-ketoacyl-CoA thiolase FoaB

Fatty acid metabolism

15598209

6

0.1

acetyl-CoA carboxylase subunit beta AccD

Carbon fixation

15598308

5.7

0.1

30S ribosomal protein S3 RpsC

Ribosome

15599453

5.7

0.1

ribonuclease E Rne

RNA processing

15598172

5.3

0.1

bacterioferritin PA4880

Metallic cation, iron-siderophore and vitamin B12 xport system

15600073

5

0.1

50S ribosomal protein L13 RplM

Ribosome

15599629

4.7

0.1

formate dehydrogenase subunit epsilon FdhE

Other carbohydrate metabolism

15600003

4.7

0.1

hypothetical protein PA3967

Unknown function

15599162

4.3

0.1

lysine-specific pyridoxal 5′-phosphate-dependent carboxylase LdcA

Arginine and proline metabolism

15597015

4

0.1

acetyl-CoA carboxylase subunit A PA5436

Citrate cycle

15600629

4

0.1

cytochrome C PA2482

ATP synthesis

15597678

3.3

0.1

threonine dehydratase IlvA1

Branched-chain amino acid metabolism

15595528

3

0.1

transcription-repair coupling factor Mfd

Repair system

15598198

3

0.1

glycerate dehydrogenase HprA

Photorespiration

15599822

3

0.1

hypothetical protein PA5201

Pathogenicity

15600394

3

0.1

fumarase PA4333

Citrate cycle

15599529

41.3

1.7

phosphopantetheine adenylyltransferase CoaD

Cofactor and vitamin synthesis

15595560

14.3

0.7

aconitate hydratase PA0794

Citrate cycle

15595991

32.7

1.7

50S ribosomal protein L3 RplC

Ribosome

15599459

10.7

0.7

formyltetrahydrofolate deformylase PurU1

Purine metabolism

15599510

4.7

0.3