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Table 1 The top 30 up-regulated proteins in PAC-treated P. aeruginosa bacteria

From: Cranberry proanthocyanidins have anti-biofilm properties against Pseudomonas aeruginosa

Upregulated

Proteins

Functional annotation

Accession number

Average spectra count

Untreated

Treated

fumarate hydratase FumC1

Central carbohydrate metabolism

15599666

0.1

21.3

ABC transporter ATP-binding protein PA4595

ABC-2 type or other transport systems

15599791

0.1

19

antioxidant protein PA3450

Phenylpropanoid and flavanoid biosynthesis

15598646

0.1

18

adhesion protein PA2407

Metallic cation, iron-siderophore and vitamin B12 transport system

15597603

0.1

17

3-oxo-C12-homoserine lactone acylase PvdQ

Metallic cation, iron-siderophore and vitamin B12 transport system

15597581

0.1

16

pyochelin biosynthesis protein PchD

Metallic cation, iron-siderophore and vitamin B12 transport system

15599424

0.1

15.3

hypothetical protein PA2410

Metallic cation, iron-siderophore and vitamin B12 transport system

15597606

0.1

13.3

hypothetical protein PA0335

Serine and threonine metabolism

15595532

0.1

12.3

protein PvdN

Metallic cation, iron-siderophore and vitamin B12 transport system

15597590

0.1

11.3

hypothetical protein PA4328

Stress protein

15599524

0.1

11

hypothetical protein PA3931

Metallic cation, iron-siderophore and vitamin B12 transport system

15599126

0.1

10

hypothetical protein PA4657

ATP synthesis

15599852

0.1

9.7

osmotically inducible protein OsmC

Stress protein

15595257

0.1

9

PmbA

Replication system

15599668

0.1

8.3

sulfite reductase CysI

Sulfur metabolism

15597035

0.1

7.3

superoxide dismutase SodM

Stress protein

15599664

0.1

6.7

hypothetical protein PA3250

Metallic cation, iron-siderophore and vitamin B12 transport system

15598446

0.1

6.7

hypothetical protein PA2699

Histidine metabolism

15597895

0.1

6.3

hypothetical protein PA2044

Cysteine and methionine metabolism

15597240

0.1

6.3

periplasmic polyamine binding protein PA0295

Mineral and organic ion transport system

15595492

0.1

6.3

heme/hemoglobin uptake outer membrane receptor PhuR

Metallic cation, iron-siderophore and vitamin B12 transport system

15599904

0.1

6

PhuS

Metallic cation, iron-siderophore and vitamin B12 transport system

15599903

0.1

5.7

pyocin S5

Pathogenicity

15596182

0.1

5.7

carbohydrate kinase PA3579

Lipid metabolism

15598775

0.1

5.3

hypothetical protein PA5229

Unknown function

15600422

0.1

5

heme uptake outer membrane receptor HasR

Metallic cation, iron-siderophore and vitamin B12 transport system

15598604

0.1

5

SpoVR family protein PA0586

Stress protein

15595783

0.1

5

hypothetical protein PA5359

Carbohydrate metabolism

15600552

0.1

4.7

N-formylglutamate amidohydrolase HutG

Histidine metabolism

15600284

0.1

4.3

amidotransferase PauD2

Histidine metabolism

15596939

0.1

4.3