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Table 1 Design of the study of in vivo activity of M. alternifolia essential oil

From: Essential oil of Melaleuca alternifolia for the treatment of oral candidiasis induced in an immunosuppressed mouse model

Day of Experiment


Day 1

1° injection of prednisolone

Day 2

Inoculation of C. albicans in the oral cavity of mice

Day 5

2° injection of prednisolone

Day 6

Treatment of oral candidiasis with M. alternifolia essential oil or physiological solution (control group)

Recovery of C. albicans from the tongue dorsum of mice before and immediately after experimental treatment

Day 7

Euthanasia of the mice: macroscopic analysis, optical microscopy, and Scanning Electron Microscopy (SEM) of the tongue dorsum of mice.