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Table 1 Design of the study of in vivo activity of M. alternifolia essential oil

From: Essential oil of Melaleuca alternifolia for the treatment of oral candidiasis induced in an immunosuppressed mouse model

Day of Experiment Methodology
Day 1 1° injection of prednisolone
Day 2 Inoculation of C. albicans in the oral cavity of mice
Day 5 2° injection of prednisolone
Day 6 Treatment of oral candidiasis with M. alternifolia essential oil or physiological solution (control group)
Recovery of C. albicans from the tongue dorsum of mice before and immediately after experimental treatment
Day 7 Euthanasia of the mice: macroscopic analysis, optical microscopy, and Scanning Electron Microscopy (SEM) of the tongue dorsum of mice.