Figure 1

Outline of tumor models and treatment protocols used in this study. (Upper panel) treatment protocols and administration routes for different drugs. KSY: 1000 mg/kg/day, p.o.; OK-432: 4 mg/kg per injection, i.p.; Lipo-Dox: 1.5 mg/kg per injection, i.v.. (Bottom panel) tumor mouse models used in this study. In the C3-B model, C3H/HeN mice were injected with a syngeneic bladder cancer cell line MBT-2. In the Nu-B model, BALB/cAnN-Foxn1nu/Cr1Nar1 mice were inoculated with MBT-2 cells. In the B6-L model, C57BL/6 mice were injected with a syngeneic lung cancer cell line LLC-1. The detailed experimental procedures are described in the “Methods”.