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Table 4 Serum hormones profile of acetaminophen metabolites at baseline and 4 weeks

From: An open label pilot study to evaluate the efficacy of Spanish black radish on the induction of phase I and phase II enzymes in healthy male subjects

Serum hormones Week 0 Week 4 Difference from week 0 to week 4 P Valuea
Total testosterone
 Cmax(pmol/L) 17.38 ± 5.57 17.14 ± 4.57 -0.24 ± 3.22 0.906
 Tmax(h) 0.85 ± 2.53 0.84 ± 2.53 0.00 ± 0.00 0.331
 AUC(0–8 hour) (pmol.h/L) 101.64 ± 36.38 99.77 ± 29.96 -1.87 ± 21.42 0.998
Free testosterone
 Cmax(pmol/L) 44.14 ± 13.33 44.38 ± 14.04 0.24 ± 5.30 0.924
 Tmax(h) 0.85 ± 2.53 0.63 ± 2.01 -0.21 ± 2.11 0.667
 AUC(0–8 hour) (pmol.h/L) 245.71 ± 71.67 254.31 ± 64.02 8.60 ± 32.14 0.228
Estradiol-17β
 Cmax(pmol/L) 97.74 ± 25.87 84.32 ± 21.05 -13.42 ± 17.08 0.004
 Tmax(h) 1.69 ± 2.53 1.90 ± 3.03 0.21 ± 3.89 0.817
 AUC(0–8 hour) (pmol.h/L) 687.08 ± 173.03 617.43 ± 120.00 -69.65 ± 88.00 0.002
  1. Cmax, Tmax and AUC0-8h of serum hormones following administration of 1000 mg acetaminophen to participants at week 0 and after 4 weeks of SBR supplementation.
  2. Values are presented as Mean ± SDa Between group comparisons were made using t-test. Statistical comparisons for Cmax and AUC(0–8 hours) were conducted using log-transformed data.
  3. Cmax = maximum concentration; Tmax = time of maximum concentration; AUC = area under the serum concentration time curve.