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Table 4 Serum hormones profile of acetaminophen metabolites at baseline and 4 weeks

From: An open label pilot study to evaluate the efficacy of Spanish black radish on the induction of phase I and phase II enzymes in healthy male subjects

Serum hormones

Week 0

Week 4

Difference from week 0 to week 4

P Valuea

Total testosterone

 Cmax(pmol/L)

17.38 ± 5.57

17.14 ± 4.57

-0.24 ± 3.22

0.906

 Tmax(h)

0.85 ± 2.53

0.84 ± 2.53

0.00 ± 0.00

0.331

 AUC(0–8 hour) (pmol.h/L)

101.64 ± 36.38

99.77 ± 29.96

-1.87 ± 21.42

0.998

Free testosterone

 Cmax(pmol/L)

44.14 ± 13.33

44.38 ± 14.04

0.24 ± 5.30

0.924

 Tmax(h)

0.85 ± 2.53

0.63 ± 2.01

-0.21 ± 2.11

0.667

 AUC(0–8 hour) (pmol.h/L)

245.71 ± 71.67

254.31 ± 64.02

8.60 ± 32.14

0.228

Estradiol-17β

 Cmax(pmol/L)

97.74 ± 25.87

84.32 ± 21.05

-13.42 ± 17.08

0.004

 Tmax(h)

1.69 ± 2.53

1.90 ± 3.03

0.21 ± 3.89

0.817

 AUC(0–8 hour) (pmol.h/L)

687.08 ± 173.03

617.43 ± 120.00

-69.65 ± 88.00

0.002

  1. Cmax, Tmax and AUC0-8h of serum hormones following administration of 1000 mg acetaminophen to participants at week 0 and after 4 weeks of SBR supplementation.
  2. Values are presented as Mean ± SDa Between group comparisons were made using t-test. Statistical comparisons for Cmax and AUC(0–8 hours) were conducted using log-transformed data.
  3. Cmax = maximum concentration; Tmax = time of maximum concentration; AUC = area under the serum concentration time curve.