Urine acetaminophen metabolites | Week 0 | Week 4 | Difference from week 0 to week 4 | P Valuea |
---|---|---|---|---|
Acetaminophen glucuronide | ||||
 Cmax(mg) | 534.34 ± 100.71 | 553.91 ± 151.27 | 19.57 ± 124.28 | 0.661 |
 Tmax(h) | 4.95 ± 1.54 | 5.26 ± 1.52 | 0.32 ± 1.67 | 0.420 |
 AUC(0–8 hour) (mg. h) | 2842.35 ± 654.09 | 2803.66 ± 655.02 | -38.69 ± 342.45 | 0.675 |
Acetaminophen sulfate | ||||
 Cmax(mg) | 109.65 ± 27.66 | 128.72 ± 48.28 | 19.08 ± 38.37 | 0.030 |
 Tmax(h) | 3.37 ± 1.34 | 4.21 ± 1.47 | 0.84 ± 1.92 | 0.072 |
 AUC(0–8 hour) (mg. h) | 541.92 ± 117.29 | 603.26 ± 197.79 | 61.34 ± 166.19 | 0.010 |
Acetaminophen mercapturate | ||||
 Cmax(mg) | 12.41 ± 4.81 | 17.23 ± 8.27 | 4.82 ± 9.72 | 0.027 |
 Tmax(h) | 4.84 ± 1.80 | 4.21 ± 1.62 | -0.63 ± 2.50 | 0.285 |
 AUC(0–8 hour) (mg. h) | 61.56 ± 25.66 | 84.24 ± 35.78 | 22.68 ± 44.43 | 0.024 |
Unchanged acetaminophen | ||||
 Cmax(mg) | 18.95 ± 11.01 | 20.91 ± 7.42 | 1.96 ± 10.97 | 0.151 |
 Tmax(h) | 3.05 ± 1.81 | 3.89 ± 1.94 | 0.84 ± 2.77 | 0.202 |
 AUC(0–8 hour) (mg.h) | 84.02 ± 45.36 | 99.33 ± 31.98 | 15.31 ± 45.65 | 0.060 |