|
Plasma acetaminophen metabolite
|
Week 0
|
Week 4
|
Difference from week 0 to week 4
|
P Valuea
|
|---|
|
Acetaminophen glucuronide
|
|
Cmax(μmol/L)
|
12.59 ± 4.12
|
10.82 ± 3.091
|
-1.77 ± 1.47
|
<0.001
|
|
Tmax(h)
|
2.13 ± 0.46
|
2.55 ± 1.13
|
0.42 ± 1.26
|
0.166
|
|
AUC(0–8 hour) (μmol. h/L)
|
58.05 ± 14.48
|
52.83 ± 14.09
|
-5.22 ± 6.32
|
<0.004
|
|
Acetaminophen sulfate
|
|
Cmax(μmol/L)
|
3.20 ± 0.69
|
2.90 ± 0.82
|
-0.30 ± 0.69
|
0.085
|
|
Tmax(h)
|
2.03 ± 0.01
|
2.23 ± 0.63
|
0.21 ± 0.63
|
0.169
|
|
AUC(0–8 hour) (μmol. h/L)
|
8.78 ± 4.073
|
9.64 ± 4.02
|
-1.69 ± 4.07
|
0.126
|
|
NAPQI-GSH
|
|
Cmax(μmol/L)
|
0.18 ± 0.09
|
0.18 ± 0.04
|
-0.02 ± 0.07
|
0.200
|
|
Tmax(h)
|
2.03 ± 0.01
|
2.02 ± 0.01
|
-0.00 ± 0.02
|
0.682
|
|
AUC(0–8 hour) (μmol. h/L)
|
0.72 ± 0.31
|
0.66 ± 0.22
|
-0.07 ± 0.22
|
0.336
|
|
Unchanged acetaminophen
|
|
Cmax(μmol/L)
|
1.59 ± 1.65
|
0.79 ± 0.20
|
-0.79 ± 1.72
|
0.022
|
|
Tmax(h)
|
2.87 ± 1.38
|
3.08 ± 1.68
|
0.21 ± 2.30
|
0.696
|
|
AUC(0–8 hour) (μmol. h/L)
|
4.10 ± 2.25
|
2.45 ± 0.66
|
-1.65 ± 2.65
|
0.010
|
- Cmax, Tmax and AUC0-8h of plasma acetaminophen metabolites following administration of 1000 mg acetaminophen to participants at week 0 and after 4 weeks of SBR supplementation.
- Values are presented as Mean ± SD.
-
aBetween group comparisons were made using t-test. Statistical comparisons for Cmax and AUC(0–8 hour) were conducted using log-transformed data.
- Cmax = maximum concentration; Tmax = time of maximum concentration; AUC = area under the plasma concentration time curve.
