Figure 3

Effects of intrathecal injection of 5-HT antagonists on BVA-induced anti-allodynic action. The behavioral tests for cold allodynia were performed before an intrathecal injection of antagonists and after BVA treatment in the five groups of animals: (a) N/S + BV (left, n = 7) and DMSO + BV (right, n = 3), (b) NAN-190 + BV, (c) ketanserin + BV, and (d) MDL-72222 + BV (n = 8/group). Data are presented as mean ± SEM (bar graph) and individual traces in TWL change. *p < 0.05, **p < 0.01, ns = no significant, by paired t-test.