Experimental assessment of antidiarrheal and antisecretory activity of 80% methanolic leaf extract of Zehneria scabra in mice

Table 3 The effect of Z. scabra extract frequency of defecation on castor oil-induced diarrhea within four hours in mice

Group	Number of deifications in specific time				Total number of defecation	Inhibition (%)
	1hr	2hr	3hr	4hr	Total number of defecation	Inhibition (%)
2%TW-80	4.6 ± 2.86	9.4 ± 1.12^a	4.2 ± 0.8^a	1.8 ± 0.49^b	20 ± 2.43^a	-
Lop3	5.2 ± 1.14	1.8 ± 0.70***	0 ± 0.00***	0 ± 0.00*	7 ± 1.57***	65
ZS100	4.5 ± 0.72	4.2 ± 1.01**	2 ± 0.37*^b	1.5 ± 0.56^b	12 ± 0.95**	40
ZS200	6.3 ± 0.615	2.7 ± 0.42***	1.7 ± 0.50**	1 ± 0.31	11 ± 0.43**	45
ZS400	5.7 ± 1.33	1.7 ± 0.21***	1.2 ± 0.40**	0.5 ± 0.22	9 ± 1.53***	55

Values are mean number of defecations ± S.E (n=5), *p< 0.05 compared with the negative control, **p< 0.01 compared with the negative control, ***p< 0.001 compared with the negative control. ^ap<0.001 values compared with the positive control; ^bp<0.01 values compared with the positive control.

ISSN: 2662-7671