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Table 4 Cytotoxicity of extracts and fractions from S. spinosa , and their selectivity index (SI)

From: Some Strychnos spinosa (Loganiaceae) leaf extracts and fractions have good antimicrobial activities and low cytotoxicities

Samples

Cytotoxicity (LC50, μg/ml)

Selectivity index (SI)*

 
  

C.a

C.A

A.f

C.n

S.a

B.c

E.f

E.c

Extracts

         

AcetE

30.56 ± 0.00a

< 0.02

< 0.02

0.02

0.05

0.19

0.1

0.19

0.04**

MetE

361.48 ± 0.02b

< 0.30

< 0.30

0.3

0.57

< 0.30

< 0.30

< 0.30

0.57

DcmMetE

38.38 ± 0.00c

< 0.03

< 0.03

0.03

0.24

0.06

< 0.03

0.06

0.06

AlkE

141. 54 ± 0.00d

< 0.11

< 0.11

< 0.11

0.44

0.88

0.11

0.44

0.20**

Fractions

         

HexF

71.28 ± 0.01e

0.06

0.11

< 0.06

0.09**

0.9

0.08**

0.22

0.11**

ChlF

67.20 ± 0.00f

0.42

0.11

0.84

0.09**

0.84

0.11

0.42

0.28**

EtAcF

479.44 ± 0.07g

0.76

3

6

0.61**

0.76

0.51**

0.20**

0.68**

nBuF

50.49 ± 0.01h

< 0.04

< 0.04

0.04

0.08**

0.42**

0.08

0.04

0.08

WatF

689.39 ± 0.00i

< 0.55

< 0.55

0.55

0.73**

< 0.55

< 0.55

< 0.55

0.55

Control

         

Dox

2.59 ± 0.00

        
  1. AcetE: Acetone Extract, MetE: Methanol extract DcmMetE: Dichloromethane/methanol extract, AlkE: Alkaloids extract, HexF: n-hexane fraction, ChlF: Chloroform fraction, EtAcF: Ethyl acetate fraction, nBuF: n-Butanol fraction, WatF: Water fraction, Dox: Doxorubicin with LC50 in μM, NT: not tested, *SI = LC50 /MIC, **SI obtained from average MIC. ) C.a Candida albicans (Isolate); C.A: Candida albicans (ATCC strain); C.n: Cryptococcus neoformans; A.f: Aspergillus fumigatus E.c: Escherichia coli, E.f: Enterococcus faecalis, S.a: Staphylococcus aureus, B.c: Bacillus cereus. Values with different letters are significantly different at p < 0.05.
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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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