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Table 4 Cytotoxicity of extracts and fractions from S. spinosa , and their selectivity index (SI)

From: Some Strychnos spinosa (Loganiaceae) leaf extracts and fractions have good antimicrobial activities and low cytotoxicities

Samples Cytotoxicity (LC50, μg/ml) Selectivity index (SI)*  
   C.a C.A A.f C.n S.a B.c E.f E.c
Extracts          
AcetE 30.56 ± 0.00a < 0.02 < 0.02 0.02 0.05 0.19 0.1 0.19 0.04**
MetE 361.48 ± 0.02b < 0.30 < 0.30 0.3 0.57 < 0.30 < 0.30 < 0.30 0.57
DcmMetE 38.38 ± 0.00c < 0.03 < 0.03 0.03 0.24 0.06 < 0.03 0.06 0.06
AlkE 141. 54 ± 0.00d < 0.11 < 0.11 < 0.11 0.44 0.88 0.11 0.44 0.20**
Fractions          
HexF 71.28 ± 0.01e 0.06 0.11 < 0.06 0.09** 0.9 0.08** 0.22 0.11**
ChlF 67.20 ± 0.00f 0.42 0.11 0.84 0.09** 0.84 0.11 0.42 0.28**
EtAcF 479.44 ± 0.07g 0.76 3 6 0.61** 0.76 0.51** 0.20** 0.68**
nBuF 50.49 ± 0.01h < 0.04 < 0.04 0.04 0.08** 0.42** 0.08 0.04 0.08
WatF 689.39 ± 0.00i < 0.55 < 0.55 0.55 0.73** < 0.55 < 0.55 < 0.55 0.55
Control          
Dox 2.59 ± 0.00         
  1. AcetE: Acetone Extract, MetE: Methanol extract DcmMetE: Dichloromethane/methanol extract, AlkE: Alkaloids extract, HexF: n-hexane fraction, ChlF: Chloroform fraction, EtAcF: Ethyl acetate fraction, nBuF: n-Butanol fraction, WatF: Water fraction, Dox: Doxorubicin with LC50 in μM, NT: not tested, *SI = LC50 /MIC, **SI obtained from average MIC. ) C.a Candida albicans (Isolate); C.A: Candida albicans (ATCC strain); C.n: Cryptococcus neoformans; A.f: Aspergillus fumigatus E.c: Escherichia coli, E.f: Enterococcus faecalis, S.a: Staphylococcus aureus, B.c: Bacillus cereus. Values with different letters are significantly different at p < 0.05.
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