Gal-geun-dang-gwi-tang improves diabetic vascular complication in apolipoprotein E KO mice fed a western diet

Table 1 Effects of GGDGT on body weight, water intake, food intake, blood glucose, and blood pressure levels in ApoE-/- mice

	Weeks
		0	4	8	11
Body weight (g)	Control	22.33 ± 0.67	24.08 ± 0.79	25.73 ± 0.79	27.42 ± 0.87
	ApoE -/-	22.57 ± 0.65	28.23 ± 0.70**	33.60 ± 1.01**	37.55 ± 0.90**
	Rosiglitazone	22.07 ± 0.59	27.25 ± 0.97#	31.77 ± 1.22##	34.47 ± 1.35##
	GGDGT	21.45 ± 0.35	25.42 ± 0.56#	29.95 ± 0.95##	32.43 ± 1.16##
Water intake (g/day)	Control	37.63 ± 2.19	44.68 ± 2.15	39.38 ± 3.00	50.59 ± 0.67
	ApoE -/-	38.98 ± 2.92	31.31 ± 2.68	23.21 ± 1.97	30.53 ± 3.07
	Rosiglitazone	38.74 ± 3.01	30.08 ± 0.72	25.05 ± 0.71	22.68 ± 1.28
	GGDGT	29.62 ± 2.11	23.18 ± 1.82	21.30 ± 1.53	24.45 ± 2.00
Food intake (g/day)	Control	19.87 ± 0.45	24.33 ± 0.93	20.85 ± 0.52	20.65 ± 0.55
	ApoE -/-	18.06 ± 0.31	18.37 ± 0.26	17.58 ± 0.49	15.98 ± 0.42
	Rosiglitazone	16.58 ± 0.35	15.00 ± 0.22	14.02 ± 0.62	12.77 ± 0.79
	GGDGT	17.60 ± 0.52	16.24 ± 0.33	16.17 ± 0.20	14.11 ± 0.43
Glucose (mg/dl)	Control	119.60 ± 1.63	114.00 ± 5.30	102.00 ± 2.48	113.67 ± 3.48
	ApoE -/-	123.80 ± 9.28	104.00 ± 6.66	114.60 ± 6.87	138.25 ± 3.42**
	Rosiglitazone	127.33 ± 7.54	95.25 ± 14.44	097.75 ± 2.75	113.75 ± 3.25##
	GGDGT	129.33 ± 4.37	98.67 ± 1.48	107.50 ± 3.27	118.20 ± 3.64##
Systolic blood pressure (mmHg)	Control	102.06 ± 1.47	103.16 ± 1.2	104.16 ± 1.33	109.00 ± 0.91
	ApoE -/-	102.83 ± 1.98	110.42 ± 1.56	117.32 ± 1.75	128.83 ± 1.62**
	Rosiglitazone	101.53 ± 1.68	104.20 ± 0.93	104.95 ± 1.17	110.03 ± 0.76##
	GGDGT	111.25 ± 1.32	106.80 ± 1.02	106.90 ± 0.95	112.15 ± 0.82##

Body weight expressed the mean of absolute weight of mice. ApoE-/-, apolipoprotein E knockout mouse; Rosiglitazone, WD + 10 mg/day/kg rosiglitazone; GGDGT, WD + 200 mg/day/kg GGDGT. Values are expressed as mean ± S.E. values (n = 12). **p < 0.01, vs. RD-fed control mice; #p < 0.05, ##p < 0.01 vs. WD-fed ApoE-/- mice.

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