Effect of GGDGT on the OGTT and expression of insulin receptors in the muscle tissue. (A) Mice were fasted overnight and glucose (1.5 g/kg) was administered for an oral glucose tolerance test (OGTT). (B) Western blots and corresponding densitometric analysis of insulin receptor substrate (IRS)-1 expression in the muscle tissue. Data are expressed as mean ± S.E. values (n = 3 mice per group). *p < 0.05, **p < 0.01 vs. regular diet (RD)-fed control mice; #p < 0.05, ##p < 0.01 vs. Western diet (WD)-fed ApoE-/- mice.