Effect of GGDGT on ICAM-1 immunoreactivity in the aorta of Western diet (WD)-fed ApoE-/- mice. (A) Immunohistochemical staining of ICAM-1 in aortas from regular diet (RD)-fed control mice, WD-fed ApoE-/- mice, ApoE-/- mice treated with rosiglitazone, and ApoE-/- mice treated with Gal-geun-dang-gwi-tang (GGDGT) (upper panels, magnification × 100; middle panels, magnification × 400; lower panels, magnification × 100). (B) Quantitative analysis of ICAM-1 immunoreactivity in the thoracic aorta. The average score for 5–10 randomly selected aortas was calculated. Data are expressed as mean ± S.E. values (n = 6 mice per group). **p < 0.01 vs. RD-fed control mice; #p < 0.05, ##p < 0.01 vs. WD-fed ApoE-/- mice.