Effect of GGDGT on relaxation of the thoracic aorta in Western diet (WD)-fed ApoE-/- mice. (A) Aortic relaxation induced by acetylcholine (Ach), and (B) aortic relaxation induced by sodium nitroprusside (SNP). Data are mean ± S.E. values (n = 10 mice per group). *p < 0.05, **p < 0.01 vs. regular diet-fed control mice; #p < 0.05, ##p < 0.01, ###p < 0.001 vs. WD-fed ApoE-/- mice.