CCl4 induced genotoxicity and DNA oxidative damages in rats: hepatoprotective effect of Sonchus arvensis

Table 2 Effect of SME on liver markers enzymes

Treatment	ALT(U/L)	AST(U/L)	ALP(U/L)	γ-GT(nM/min /mg protein)
Control	45.8 ± 3.2⁺⁺	53.8 ± 3.4⁺⁺	148 ± 5.9⁺⁺	105.5 ± 2.2⁺⁺
3 ml/kg CCl₄	102 ± 4.2**	94.0 ± 4.7**	340.3 ± 6.9**	154.3 ± 3.2**
100 mg/kg SME + CCl₄	68 ± 3.8⁺⁺	62.3 ± 4.9⁺⁺	207.5 ± 4.9⁺⁺	121.3 ± 3.4⁺⁺
200 mg/kg SME + CCl₄	91 ± 2.2⁺⁺	56 ± 4.1⁺⁺	167.7 ± 5.7⁺⁺	108 ± 2.7⁺⁺
100 mg/kg sylimarin + CCl₄	89 ± 1.5⁺⁺	57.5 ± 2.0⁺⁺	157.8 ± 3.9⁺⁺	110 ± 3.5⁺⁺
200 mg/kg SME alone	97 ± 2.4⁺⁺	49.5 ± 3.6⁺⁺	145.3 ± 5.1⁺⁺	103 ± 2.7⁺⁺

Mean ± SE (n = 6 number).
**indicate significance from the control group at P < 0.05 and P < 0.01 probability level.
⁺⁺indicate significance from the CCl₄ group at P < 0.05 and P < 0.01 probability level.

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