CCl4 induced genotoxicity and DNA oxidative damages in rats: hepatoprotective effect of Sonchus arvensis

Table 1 Effect of SME on body weight, liver weight and relative liver weight

Treatment	% Increase in body weight	Liver weight (g)	Relative liver weight (% to body weight)
Control	28.90 ± 2.17⁺⁺	7.0 ± 0.83⁺⁺	0.07 ± 0.002⁺⁺
3 ml/kg CCl₄	19.57 ± 3.02**	9.6 ± 0.89**	0.96 ± 0.006**
100 mg/kg SME + CCl₄	25.28 ± 1.51⁺⁺	7.48 ± 0.70⁺⁺	0.074 ± 0.002⁺⁺
200 mg/kg SME + CCl₄	27.14 ± 2.63⁺⁺	7.14 ± 0.53⁺⁺	0.071 ± 0.003⁺⁺
100 mg/kg sylimarin + CCl₄	27.01 ± 1.26⁺⁺	7.22 ± 0.75⁺⁺	0.072 ± 0.001⁺⁺
200 mg/kg SME alone	29.02 ± 2.49⁺⁺	7.03 ± 0.67⁺⁺	0.070 ± 0.006⁺⁺

Mean ± SE (n = 6 number).
**indicate significance from the control group at P < 0.05 and P < 0.01 probability level.
⁺⁺indicate significance from the CCl₄ group at P < 0.05 and P < 0.01 probability level.

ISSN: 2662-7671