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Table 1 Dorsal tumors and metastases induced in C57BL/6 after toxin treated B16-F10 murine melanoma cells

From: Antiproliferative effect of the jararhagin toxin on B16F10 murine melanoma

  Control 0.8 μM JARA 0.2 μM JARI
Total n° mice 10 10 10
Dorsal tumor    
Incidence 10/10 (100%) 8/10 (80%) 10/10 (100%)
Mean volume (mm3) 17.8 ± 4.5 5.8 ± 1.2 (p = 0.01) 3.4 ± 0.7* (p = 0.0016)
Metastasis    
Nodules Incidence 10/10 (100%) 4/10 (40%)* (p = 0.0108) 2/10 (20%)* (p = 0.0007)
Mean volume (mm3) 42.10 ± 23.20 2.78 ± 6.10* (p < 0.0001) 1.31 ± 2.90* (p < 0.0001)
Multiplicity 5.8 ± 1.22 0.70 ± 1.05* (p < 0.0001) 0.40 0.96* (p = 0.0001)
Metastases distribution    
1- Lung 42 (72.4%) 02 (28.5%) 03 (75%)
2- Liver 01 (1.7%) 01 (14.2%) 0
3- Spleen 01 (1.7%) 01 (14.2%) 0
4- Kidney 05 (8.6%) 0 0
5- Lymph nodes 09 (15.5%) 03 (42.8%) 01 (25%)
Total n° nodules 58 07**p < 0.01 04***p < 0.001
87.2% 93.1%
  1. *The probabilities were compared to control values (Student unpaired T test; Fisher’s – Yates exact tests).