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Table 1 Dorsal tumors and metastases induced in C57BL/6 after toxin treated B16-F10 murine melanoma cells

From: Antiproliferative effect of the jararhagin toxin on B16F10 murine melanoma

 

Control

0.8 μM JARA

0.2 μM JARI

Total n° mice

10

10

10

Dorsal tumor

   

Incidence

10/10 (100%)

8/10 (80%)

10/10 (100%)

Mean volume (mm3)

17.8 ± 4.5

5.8 ± 1.2 (p = 0.01)

3.4 ± 0.7* (p = 0.0016)

Metastasis

   

Nodules Incidence

10/10 (100%)

4/10 (40%)* (p = 0.0108)

2/10 (20%)* (p = 0.0007)

Mean volume (mm3)

42.10 ± 23.20

2.78 ± 6.10* (p < 0.0001)

1.31 ± 2.90* (p < 0.0001)

Multiplicity

5.8 ± 1.22

0.70 ± 1.05* (p < 0.0001)

0.40 0.96* (p = 0.0001)

Metastases distribution

   

1- Lung

42 (72.4%)

02 (28.5%)

03 (75%)

2- Liver

01 (1.7%)

01 (14.2%)

0

3- Spleen

01 (1.7%)

01 (14.2%)

0

4- Kidney

05 (8.6%)

0

0

5- Lymph nodes

09 (15.5%)

03 (42.8%)

01 (25%)

Total n° nodules

58

07**p < 0.01

04***p < 0.001

87.2%

93.1%

  1. *The probabilities were compared to control values (Student unpaired T test; Fisher’s – Yates exact tests).