Morphological features of B16F10 cells exposed to toxins. The morphology of tumor cells was dramatically altered by toxin treatments, as observed by light microscopy. Scanning electron microscopy (SEM) showed the melanoma cells grown as a large, spreading monolayer, and the organization of the extracellular matrix with many protrusions. The cells showed retraction, and aggregates with 0.4 μM and 0.8 μM jara. Cells treated with jari showed detachment of the plate surface and formation of smaller aggregates (0.2 μM jari), and apoptotic bodies and necrosis debris (0.4 μM jari). Magnification 400× (microscopy), scale bar 30 μm and 3 μm (SEM).