Both VitC pre- and post-treatment decreased the serum level of biochemical indicators through HO-1 induction. Serum level of biochemical indicators including ALT (A), AST (B), BUN (C), Cre (D), LDH (E), and lactate (F) were tested. Serum was collected at 12 hours after HS operation. Data represents the mean ± SEM, n = 6. *p < 0.05 vs. the Sham; **p < 0.05 compared to the HS; ***p < 0.05 compared to the HSV; ****p < 0.05 compared to the HSV-post; $
p > 0.05 compared to the Sham. Sham: the rats which received NS and underwent sham operation. ShamV: the rats which received VitC and underwent sham operation. HS: the rats which received NS and underwent HS operation. HSV-pre: the rats which received VitC at 6 hours before HS operation. HSV-preZ: some HSV-pre rats further received ZnPP. HSV-post: the rats which underwent HS operation and received VitC immediately. HSV-postZ: some HSV-post rats further received ZnPP.