Figure 4From: Earthworm (Pheretima aspergillum) extract stimulates osteoblast activity and inhibits osteoclast differentiation Earthworm extract stimulates matrix calcium deposition by osteoblasts. MG-63 cells were cultured in osteogenic medium mixed with PBS as a control or different concentrations of earthworm extract. After 14 day of culture, matrix calcium deposition was determined using von Kossa staining. Arrows demonstrate deposition of mineralized matrix.Back to article page