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Table 1 In vitro susceptibilities of Candida isolates to a standard preparation of HDCL

From: Growth inhibition of Candida species by Wickerhamomyces anomalus mycocin and a lactone compound of Aureobasidium pullulans

Candida spp. Planktonic MIC (μg/ml) Biofilm MIC (μg/ml)
MIC range MIC50 MIC90 MIC range MIC50 MIC90
Candida albicans ( n = 15) 128 - 256 256 256 128 - 512 256 256
Nonalbicans Candida species (n = 77) 64 - 256 256 256 64 - 1024 256 256
Candida glabrata (n = 26) 64 - 256 256 256 64 - 512a 256a 512a
C. krusei (n = 17) 128 - 256 128 256 64 - 256 128 256
C. parapsilosis (n = 8) 64 - 256 64 256 128 - 1024b 128b 1024b
C. tropicalis (n = 10) 64 - 256 128 256 256 - 1024 256 512
C. orthopsilosis (n = 8) 128 - 256 256 256 128 - 256c 128c 256c
C. rugosa species complex (n = 5) 128 - 256 128 256 128 - 512 512 512
C. dubliniensis (n =1) 128 ND ND 256 ND ND
M. guelliermondii (n =1) 128 ND ND 128 ND ND
C. metapsilosis (n =1) 256 ND ND 128 ND ND
All isolates (n = 92) 64 - 256 256 256 64 - 1024 256 512
  1. Footnote: Planktonic MIC: The lowest concentration of HDCL required to inhibit yeast growth after incubation at 37°C for 48 h.
  2. Biofilm MIC: The lowest concentration of HDCL required to cause 50% reduction in biofilm metabolic activity after incubation at 37°C for 48 h.
  3. MIC50 and MIC90 values were only calculated for those species with 5 or more isolates.
  4. ND: Not determined.
  5. a, b, c: Five Candida glabrata and two each of C. parapsilosis and C. orthopsilosis isolates were excluded from the study due to poor biofilm formation (OD490nm < 0.1).