Candida spp.
|
Planktonic MIC (μg/ml)
|
Biofilm MIC (μg/ml)
|
---|
MIC range
|
MIC50
|
MIC90
|
MIC range
|
MIC50
|
MIC90
|
---|
Candida albicans ( n = 15)
|
128 - 256
|
256
|
256
|
128 - 512
|
256
|
256
|
Nonalbicans Candida species (n = 77)
|
64 - 256
|
256
|
256
|
64 - 1024
|
256
|
256
|
Candida glabrata (n = 26)
|
64 - 256
|
256
|
256
|
64 - 512a
|
256a
|
512a
|
C. krusei (n = 17)
|
128 - 256
|
128
|
256
|
64 - 256
|
128
|
256
|
C. parapsilosis (n = 8)
|
64 - 256
|
64
|
256
|
128 - 1024b
|
128b
|
1024b
|
C. tropicalis (n = 10)
|
64 - 256
|
128
|
256
|
256 - 1024
|
256
|
512
|
C. orthopsilosis (n = 8)
|
128 - 256
|
256
|
256
|
128 - 256c
|
128c
|
256c
|
C. rugosa species complex (n = 5)
|
128 - 256
|
128
|
256
|
128 - 512
|
512
|
512
|
C. dubliniensis (n =1)
|
128
|
ND
|
ND
|
256
|
ND
|
ND
|
M. guelliermondii (n =1)
|
128
|
ND
|
ND
|
128
|
ND
|
ND
|
C. metapsilosis (n =1)
|
256
|
ND
|
ND
|
128
|
ND
|
ND
|
All isolates (n = 92)
|
64 - 256
|
256
|
256
|
64 - 1024
|
256
|
512
|
- Footnote: Planktonic MIC: The lowest concentration of HDCL required to inhibit yeast growth after incubation at 37°C for 48 h.
- Biofilm MIC: The lowest concentration of HDCL required to cause 50% reduction in biofilm metabolic activity after incubation at 37°C for 48 h.
- MIC50 and MIC90 values were only calculated for those species with 5 or more isolates.
- ND: Not determined.
-
a, b, c: Five Candida glabrata and two each of C. parapsilosis and C. orthopsilosis isolates were excluded from the study due to poor biofilm formation (OD490nm < 0.1).