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Table 2 IC 50 values ( μ g/mL) of ROS inhibitory and chemotaxis activities of Phyllanthus amarus and P. urinaria and their major compounds on phagocytes (mean ± SEM, n =3)

From: Correlation between the major components of Phyllanthus amarus and Phyllanthus urinaria and their inhibitory effects on phagocytic activity of human neutrophils

Sample Chemotaxis Chemiluminescence
fMLP Zymosan PMA
PMNs MNCs Whole Blood PMNs MNCs Whole Blood PMNs MNCs
PA (Mal) 1.22 ± 0.10 1.44 ± 0.80 0.95 ± 0.24 0.58 ± 1.80 0.10 ± 0.17 1.24 ± 0.98 0.42 ± 0.75 0.56 ± 0.30
PA (Ind) 1.84 ± 0.01 2.35 ± 0.23 8.14 ± 1.71 0.12 ± 0.05 2.19 ± 2.55 6.02 ± 1.33 1.34 ± 0.59 1.27 ± 0.80
PU (Mal) 1.46 ± 0.10 2.84 ± 0.30 1.52 ± 0.53 1.00 ± 1.21 1.23 ± 0.88 1.98 ± 1.09 0.45 ± 0.23 0.26 ± 0.12
PU (Ind) 2.21 ± 0.90 2.92 ± 0.14 9.74 ± 1.09 1.64 ± 0.58 0.36 ± 0.29 4.80 ± 1.80 1.34 ± 1.18 1.06 ± 0.31
GA 1.40 ± 0.02 (8.22 ± 0.15) 2.00 ± 0.03 (11.75 ± 0.23) 1.70 ± 0.03 (9.99 ± 0.12) 0.43 ± 1.02 (2.53 ± 0.10) 1.29 ± 0.87 (7.58 ± 0.50) 0.87 ± 0.12 (5.11 ± 0.15) 0.48 ± 0.01 (2.82 ± 0.15) 1.28 ± 0.01 (7.52 ± 0.12)
EA 1.33 ± 0.07 (4.40 ± 0.12) 1.81 ± 0.12 (5.96 ± 0.12) 1.36 ± 0.08 (4.50 ± 0.16) 0.56 ± 0.02 (1.85 ± 0.35) 0.45 ± 0.09 (1.49 ± 0.07) 0.83 ± 0.03 (2.75 ± 0.07) 0.31 ± 0.07 (1.02 ± 0.06 ) 0.75 ± 0.12 (2.48 ± 0.06 )
Ger 1.04 ± 0.12 (1.09 ± 0.23 ) 1.61 ± 0.14 (1.69 ± 0.05) 0.34 ± 0.30 (0.36 ± 0.12 ) 0.18 ± 0.07 (0.18 ± 0.02) 0.37 ± 0.41 (0.38 ± 0.07) 0.19 ± 0.12 (0.21 ± 0.01) 0.12 ± 0.04 (0.13 ± 0.01) 0.36 ± 0.61 (0.38 ± 0.12 )
Cor 1.49 ± 0.024 (2.34 ± 0.07) 1.99 ± 0.09 (3.13 ± 0.44) 0.37 ± 0.37 (0.58 ± 0.03) 0.36 ± 0.07 (0.56 ± 0.023) 0.44 ± 0.08 (0.69 ± 0.12) 0.22 ± 0.88 (0.35 ± 0.09) 0.15 ± 0.04 (0.24 ± 0.02) 0.44 ± 0.03 (0.69 ± 0.05)
Phyll 3.20 ± 0.15 (7.60 ± 0.10) 8.51 ± 0.52 (20.2 ± 0.40) 3.70 ± 2.80 (8.80 ± 1.00) 3.2 ± 2.81 (7.6 ± 0.40) 2.38 ± 1.44 (5.68 ± 0.31) 1.40 ± 1.72 (3.34 ± 0.05) 0.08 ± 0.66 (0.20 ± 0.01) 1.54 ± 0.87 (3.68 ± 0.43)
Hypophyll 4.40 ± 0.2 (10.2 ± 0.40) 9.60 ± 0.26 (22.3 ± 0.53) 3.6 ± 1.40 (8.4 ± 1.30) 6.1 ± 2.32 (14.2 ± 1.70) 1.41 ± 0.06 (3.27 ± 0.15) 1.87 ± 0.01 (4.34 ± 0.02) 0.95 ± 0.11 (2.20 ± 0.31) 1.73 ± 0.31 (4.02 ± 0.71)
Ibuprofen 1.40 ± 0.10 (6.60 ± 0.10) 1.98 ± 0.05 (9.57 ± 0.23)       
Aspirin    2.16 ± 0.80 (11.88 ± 4.14) 0.85 ± 0.20 (4.68 ± 2.71) 0.43 ± 0.07 (2.40 ± 0.16) 0.17 ± 0.01 (0.94 ± 0.05) 0.14 ± 0.09 (0.77 ± 0.16) 0.58 ± 0.28 (3.22 ± 0.38)
  1. GA: Gallic acid, EA: Ellagic acid, Ger: Geraniin, Cor: Corilagin, Phyll: Phyllanthin, Hypophyll: Hypophyllanthin, PA: Phyllanthus amarus, PU: Phyllanthus urinaria, Mal: Malaysia, Ind: Indonesia.
  2. IC50 values in μ M are in parentheses.
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