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Table 1 Cytotoxicity results of A.carnosus extracts by MTT assay

From: Cytotoxic potential of Anisochilus carnosus (L.f.) wall and estimation of luteolin content by HPLC

Concentration (μg/ml)

% Viability

Aqueous extract

Ethanolic extract

Pet. ether extract

Paclitaxel

0

100 ± 5.875

100 ± 5.875

100 ± 5.875

100 ± 2.09

6.25

-

-

-

80.32 ± 0.366**

12.5

-

-

-

42.56 ± 1.863**

25

94.04 ± 1.729

75.26 ± 2.654*

44.92 ± 2.631**

22.83 ± 1.22**

50

80.87 ± 2.462*

54.14 ± 4.610**

30.23 ± 3.662**

10.66 ± 0.46**

100

71.12 ± 1.950**

26.66 ± 2.951**

12.73 ± 4.242**

-

200

58.79 ± 2.278**

12.06 ± 1.104**

8.16 ± 1.063**

-

IC 50 value

238.91

58.64a

18.35a, b

11.34b

  1. Results were expressed as Mean ± SEM (n = 3) and analysed using one-way ANOVA followed by Tukey’s post hoc test of significance [where different alphabets denote significant difference (p <0.05)]. Statistical comparison between the mean % viability of each extract and its negative control was performed using one-way ANOVA followed by Dunnett’s post hoc test of significance wherein *p <0.05 and **p <0.01 were considered to be statistically significant and very statistically significant compared to negative control. A.carnosus extracts were tested at concentrations of 200, 100, 50, 25 μg/ml (they were not tested at concentrations of 6.25 and 12.5 μg/ml). Paclitaxel was tested at concentrations of 6.25, 12.5, 25 and 50 μg/ml.
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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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