Growth arrest and apoptosis via caspase activation of dioscoreanone in human non-small-cell lung cancer A549 cells

Table 1 Cytotoxic effects of dioscoreanone (DN) on human lung cell lines

Cell line	Lung cell type	Paclitaxel (μM)			DN (μM)
Cell line	Lung cell type	GI₅₀	TGI	LC₅₀	GI₅₀	TGI	LC₅₀
MRC-5	Normal lung fibroblast	0.016 ± 0.005	0.297 ± 0.008	>32	11.4 ± 1.3	19.6 ± 0.7	>32
	3 subtypes of NSCLC
A549	Adenocarcinoma	0.016 ± 0.001	0.058 ± 0.012	2.800 ± 0.400^a	6.2 ± 0.7^a	10.3 ± 0.3^a	15.7 ± 1.3^a
NCI-H226	Squamous cell carcinoma	0.017 ± 0.001	4.898 ± 0.480^a	20.672 ± 0.436^a	5.7 ± 1.2^a	9.8 ± 0.3^a	13.6 ± 1.2^a
COR-L23	Large cell carcinoma	0.017 ± 0.001	3.450 ± 0.167^a	17.725 ± 0.084^a	3.7 ± 0.9^a	8.0 ± 1.4^a	18.9 ± 2.5^a
NCI-1688	SCLC	0.012 ± 0.001	20.560 ± 0.147^a	>32	15.2 ± 2.1	21.1 ± 2.4	>32

DN concentrations required for 50% growth inhibition (GI₅₀), total growth inhibition (TGI), and 50% decrease in cell numbers (LC₅₀) relative to the untreated cells as measured by the SRB assay. Data are presented as the mean ± SD of at least 3 independent experiments.
^aStatistical significance (p <0.05) versus MRC-5.

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