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Table 1 Cytotoxic effects of dioscoreanone (DN) on human lung cell lines

From: Growth arrest and apoptosis via caspase activation of dioscoreanone in human non-small-cell lung cancer A549 cells

Cell line

Lung cell type

Paclitaxel (μM)

DN (μM)

GI50

TGI

LC50

GI50

TGI

LC50

MRC-5

Normal lung fibroblast

0.016 ± 0.005

0.297 ± 0.008

>32

11.4 ± 1.3

19.6 ± 0.7

>32

 

3 subtypes of NSCLC

      

A549

Adenocarcinoma

0.016 ± 0.001

0.058 ± 0.012

2.800 ± 0.400a

6.2 ± 0.7a

10.3 ± 0.3a

15.7 ± 1.3a

NCI-H226

Squamous cell carcinoma

0.017 ± 0.001

4.898 ± 0.480a

20.672 ± 0.436a

5.7 ± 1.2a

9.8 ± 0.3a

13.6 ± 1.2a

COR-L23

Large cell carcinoma

0.017 ± 0.001

3.450 ± 0.167a

17.725 ± 0.084a

3.7 ± 0.9a

8.0 ± 1.4a

18.9 ± 2.5a

NCI-1688

SCLC

0.012 ± 0.001

20.560 ± 0.147a

>32

15.2 ± 2.1

21.1 ± 2.4

>32

  1. DN concentrations required for 50% growth inhibition (GI50), total growth inhibition (TGI), and 50% decrease in cell numbers (LC50) relative to the untreated cells as measured by the SRB assay. Data are presented as the mean ± SD of at least 3 independent experiments.
  2. aStatistical significance (p <0.05) versus MRC-5.