Central-stimulating and analgesic activity of the ethanolic extract of Alternanthera sessilis in mice

Table 1 Effect of ETAS on pentobarbitone-induced sleeping time in mice

Treatment (n=6)	Dose (mg/kg)	Onset of sleep (min)	% Increase of onset of sleep	Duration of sleep (min)	% Decrease of duration of sleep
Control	-	11.24 ± 1.80	-	101.57 ± 2.67	-
Caffeine	20	58.63 ± 1.84*	421.62	62.56 ± 2.23*	38.41
A. sessilis	250	32.45 ± 2.89*^,#	188.70	88.67 ± 2.90^#	12.70
A. sessilis	500	53.67 ± 2.60*	377.49	78.13 ± 2.31*^,#	23.08

Values are mean ± SEM. *p < 0.001 vs. control, ^#p < 0.01 vs. caffeine, the data was analyzed by one way ANOVA followed by Bonferroni’s test.

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