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Table 4 Gastroprotective effect of CPRHE against ethanol-induced gastric injury

From: Evaluation of acute toxicity and gastroprotective activity of curcuma purpurascens BI. rhizome against ethanol-induced gastric mucosal injury in rats

Animal Groups

Animal Groups

pH of Gastric tissue

Mucus Weight (g)

Ulcer area (mm)2

Inhibition (%)

MDA (μmol/g protein)

SOD (U/g protein)

Nitric oxide (μmol/g protein)

A

Normal control

7.02 ± .004

0.89 ± 0.03

-

-

10 ± 1.1

528 ± 16.51

10 ± 1.3

B

Lesion control

2.99 ± 0.17

0.41 ± 0.01

880 ± 16.23

-

28 ± 2.98

333 ± 9.98

5.9 ± 0.47

C

Treatment control

6.14 ± 0.24*

0.79 ± 0.03*

195 ± 8.97*

77

13 ± 0.71*

481 ± 12.22*

9.1 ± 1.4*

D

CPRHE (200 mg/kg)

4.47 ± 0.09*

0.68 ± 0.02*

455 ± 12.24*

48

21 ± 0.22*

393 ± 7.67*

7.6 ± 0.8*

E

CPRHE (400 mg/kg)

5.82 ± 0.41*

0.72 ± 0.02*

325 ± 10.67*

63

17 ± 0.41*

459 ± 10.73*

8.4 ± 0.9*

  1. All values are expressed as mean ± SD. *indicates (P <0.05) compared to the (B) lesion control group. CPRHE: C. purpurascens rhizome hexane extract.