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Table 3 Serum biochemical analysis of rats. Effect of CPRHE on (a) renal function test, (b) liver function test and (c) hematology analysis of the rodents

From: Evaluation of acute toxicity and gastroprotective activity of curcuma purpurascens BI. rhizome against ethanol-induced gastric mucosal injury in rats

Animal groups

Serum biochemical analysis

 

(a) Kidney biochemical parameters

 

Sodium (mM/L)

Potassium (mM/L)

Chloride (mM/L)

Co2(mM/L)

Anion (mM/L)

Urea (mM/L)

Creatinine ( μ M/L)

Vehicle

142.23 ± 0.45

4.85 ± 0.06

104.59 ± 0.45

23.89 ± 0.64

19.36 ± 0.48

5.28 ± 0.58

30.75 ± 1.87

CPRHE (1 g/kg)

143.54 ± 0.37

5.12 ± 0.72

106.24 ± 0.54

21.49 ± 0.73

19.58 ± 0.75

5.93 ± 0.43

29.81 ± 2.27

CPRHE (2 g/kg)

143.85 ± 0.82

4.91 ± 0.034

105.27 ± 0.56

22.85 ± 0.48

19.95 ± 0.39

5.68 ± 0.37

31.46 ± 2.19

Animal groups

(b) Liver biochemical parameters

 

Total protein (g/L)

Albumin (g/L)

Globulin (g/L)

TB ( μ mol/L)

CB ( μ mol/L)

AP (IU/L)

ALT (IU/L)

AST (IU/L)

GGT (IU/L)

Vehicle

60.76 ± 0.94

9.56 ± 0.39

51.07 ± 1.28

2.19 ± 0.13

0.87 ± 0.17

154.45 ± 5.37

50.49 ± 1.34

173.82 ± 5.38

3.45 ± 0.27

CPRHE (1 g/kg)

58.37 ± 0.57

8.35 ± 0.53

50.68 ± 1.32

2.14 ± 0.16

0.91 ± 0.14

153.23 ± 5.87

45.65 ± 1.74

175.48 ± 6.49

3.37 ± 0.53

CPRHE (2 g/kg)

59.67 ± 1.29

8.87 ± 0.19

50.25 ± 1.45

2.15 ± 0.14

0.84 ± 0.16

155.73 ± 6.82

46.76 ± 1.48

176.27 ± 6.52

3.57 ± 0.43

Animal groups

(c) Hematological parameters

 

HGB (g/dL)

HCT (%)

RBC (10 6 /μL)

MCV (fL)

MCH (pg)

MCHC (g/dL)

RDW (%)

WBC (10 3 /μL)

Platelet (10 3 /μL)

Vehicle

15.03 ± 0.13

46 ± 0.00

9.38 ± 0.13

59.12 ± 0.65

19.25 ± 0.31

34.22 ± 0.19

17.03 ± 0.44

6.12 ± 0.47

986.75 ± 23.65

CPRHE (1 g/kg)

15.47 ± 0.13

46 ± 0.00

9.64 ± 0.18

58.54 ± 0.63

18.89 ± 0.36

34.04 ± 0.33

18.23 ± 0.58

6.23 ± 0.34

995.36 ± 25.32

CPRHE (2 g/kg)

15.98 ± 0.12

46 ± 0.00

9.83 ± 0.16

57.78 ± 0.76

18.59 ± 0.29

33.93 ± 0.28

18.77 ± 0.34

6.31 ± 0.39

1011.52 ± 23.18

  1. Values expressed as mean ± SEM. ALT, alanine aminotransferase; AST, aspartate aminotransferase; AP, alkaline phosphatase; CB, conjugated bilirubin; GGT: G-glutamyl transferase; HCT, hematocrit; HGB, hemoglobin; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; MCV, mean corpuscular volume; RBC, red cell count; RDW, red cell distribution width; TB: total bilirubin; WBC, white cell.
  2. The results did not show any significant difference between groups.