Figure 5
Electroacupuncture upregulated the expression of BDNF in hippocampus and cortex. Representative double immunofluorescence staining of BDNF (red) and NeuN (green) in the (A) cortex and (B) hippocampus. With EA treatment, BDNF was upregulated in the APP + EA group and Con + EA group compared with their non EA-treated counterparts (*P < .05 vs. Con group; #P < .05 vs. APP group). (C) The protein expression of BDNF was evaluated using western blot. EA significantly up-regulated the expression of BDNF in the APP/PS1 mice and wild-type mice compared with their matched counterparts. Data are means ± SD (n = 5 in each group) (*P < .05 vs. Con group; #P < 0.05 vs. APP group). Bar = 20 μm.