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Table 1 Effect of Polygonum minus extract on COX-1 & COX-2, 5-LOX and sPLA2 inhibition

From: Anti-inflammatory effects of Polygonum minus (Huds) extract (Lineminus™) in in-vitro enzyme assays and carrageenan induced paw edema

Receptor/enzyme Source Substrate % Inhibition of standard % Inhibition of Polygonum minus at doses
Standard % of inhibition 30 μg/ml 100 μg/ml
COX-1 Ovine platelets Arachidonic acid Diclofenac (1 μM) 100 30 100
COX-2 Human recombinant Arachidonic acid Diclofenac (1 μM) 100 00 25
5-LOX Human recombinant Lipooxygenase Arachidonic acid NGDA (100 μM) 100 100 100
sPLA2 Human recombinant Type V sPLA2 Diheptanoyl thio-PC TEPC (20 μM) 90 00 00