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Table 7 Effects of sub-inhibitory concentrations of oils of C. copticum , T. vulgaris and thymol on proteinase and haemolysin productions in the strains of Candida spp

From: Sub-MICs of Carum copticum and Thymus vulgaris influence virulence factors and biofilm formation in Candida spp

Test agents (Sub-MICs)

*Percent reduction in proteinase production over untreated control

**Percent reduction in haemolysin production over untreated control

C. albicans 04

C. albicans 09

C. albicans MTCC183

C. albicans SC5314

C. tropicalis 01

C. albicans 05

C. albicans 16

C. albicans MTCC183

C. albicans SC5314

C. tropicalis 01

Essential oils

C. copticum

          

0.25× MIC

89.23 ± 4.56

80.74 ± 3.45

88.50 ± 2.34

70.48 ± 4.56

63.67 ± 2.34

53.90 ± 3.45

74.70 ± 4.56

56.89 ± 2.34

56.89 ± 3.45

58.90 ± 3.67

0.5× MIC

94.80 ± 3.56

84.59 ± 5.67

90.91 ± 5.78

82.45 ± 4.56

82.50 ± 3.45

64.13 ± 4.56

87.83 ± 5.67

77.56 ± 3.33

65.78 ± 3.45

70.89 ± 4.56

T. vulgaris

          

0.25× MIC

92.54 ± 5.67

86.31 ± 5.67

71.99 ± 3.67

65.78 ± 5.67

75.05 ± 4.56

55.41 ± 3.45

79.47 ± 3.45

48.11 ± 3.45

50.89 ± 4.56

50.46 ± 4.56

0.5× MIC

96.00 ± 2.34

91.45 ± 5.67

80.55 ± 5.67

74.83 ± 4.56

87.34 ± 2.34

71.05 ± 4.56

79.47 ± 4.56

63.16 ± 3.45

59.80 ± 3.45

67.10 ± 3.45

Thymol

          

0.25× MIC

95.98 ± 5.78

89.31 ± 4.56

91.99 ± 5.67

90.78 ± 5.67

88.99 ± 4.45

65.41 ± 2.34

85.00 ± 3.45

71.11 ± 4.57

68.89 ± 3.56

66.46 ± 4.56

0.5× MIC

97.00 ± 5.56

93.67 ± 5.67

92.65 ± 4.67

87.97 ± 4.56

90.67 ± 3.34

78.05 ± 4.56

89.47 ± 4.56

83.16 ± 4.34

69.80 ± 3.63

77.10 ± 5.61

Antifungal drug

Fluconazole

          

0.25× MIC

50.32 ± 4.47

50.33 ± 4.47

44.13 ± 3.34

43.39 ± 4.56

41.57 ± 4.56

45.32 ± 3.47

49.33 ± 3.47

38.13 ± 4.34

40.39 ± 4.56

40.57 ± 4.56

0.5× MIC

54.23 ± 5.56

57.47 ± 4.57

56.16 ± 4.47

54.80 ± 4.45

54.10 ± 5.33

51.23 ± 4.56

55.47 ± 3.57

46.16 ± 3.47

49.80 ± 3.45

51.10 ± 3.33

  1. *Absorbance at 280 nm for untreated controls were 0.442 ± 0.009 (C. albicans 04), 0.865 ± 0.003 (C. albicans 09), 1.267 ± 0.006 (C. albicans MTCC183), 1.032 ± 0.043 (C. albicans SC5314), 1.010 ± 0.007 (C. tropicalis 01).
  2. **% haemolysin production in untreated controls were 74.68 ± 3.45 (C. albicans 05), 83.18 ± 5.67 (C. albicans 16), 24.93 ± 2.67 (C. albicans MTCC183), 74.45 ± 4.56 (C. albicans SC5314), 60.42 ± 3.45 (C. tropicalis 01).