Figure 7

Effects of HCE75 on monoamine neurotransmitter levels in the prefrontal cortex (A and C) and hippocampus (B and D) of mice without (A and B) or with TST (C and D). The mice of the groups unexposed to TST were decapitated and were subjected to brain surgery 66 min after administration (p.o.) of the vehicle (physiological saline with 2% Tween 80), fluoxetine (20 mg/kg), and HCE75 (20, 200, 400, 800, and 1600 mg/kg). The mice of the blank group were untreated, but similarly underwent brain surgery. The mice of the groups exposed to TST were decapitated and were subjected to brain surgery immediately after the animals were tested 60 min after treatment. Data are expressed as mean ± S.E.M. (n = 10). Data were analyzed using one-way ANOVA for multiple comparisons, followed by post hoc Student–Newman–Keuls test. ^x p < 0.05, ^y p < 0.01, and ^z p < 0.001 compared with the blank group; ^a p < 0.05, ^b p < 0.01, and ^c p < 0.001 compared with the vehicle groups exposed to TST.