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Table 1 The effect of epigallocatechin-3-gallate (EGCG) on breast cancer peripheral blood mononuclear cells (PBMC) proliferation and IFN-γ production

From: Analysis of the effect of the active compound of green tea (EGCG) on the proliferation of peripheral blood mononuclear cells

3H thymidine uptake by PBMC (cpm ± SEM) Stimulation indices [SI] of PBMCs) (SI ± SEM) IFN-γ release by PBMCs (pg/ml ± SEM)
Cell control Mitogen alone Mitogen + EGCG Mitogen alone Mitogen + EGCG Cell control Mitogen alone Mitogen + EGCG
69 ± 7 11289 ± 1637 33 ± 4 172 ± 26 0.4 ± 0.04§ 53 ± 8 2153 ± 454 38 ± 12§
Cell control Anti-CD3 alone Anti-CD3 + EGCG Anti-CD3 alone Anti-CD3 + EGCG Cell control Mitogen alone Anti-CD3 + EGCG
199 ± 29 39252 ± 4182 73 ± 14 262 ± 49 1 ± 0.05 54 ± 42 24508 ± 717 10 ± 4
Cell control Her-2/neu alone Her-2/neu + EGCG Her-2/neu alone Her-2/neu + EGCG Cell control Her-2/neu alone Her-2/neu + EGCG
101 ± 8 432 ± 79 40 ± 6 4.3 ± 0.7 0.4 ± 0.07 13 ± 6 62 ± 12 28 ± 9
Cell control p53 alone p53 + EGCG p53 alone p53 + EGCG Cell control p53 alone p53 + EGCG
72 ± 9 972 ± 191 39 ± 5 9 ± 1 0.4 ± 0.06 52 ± 8 109 ± 11 33 ± 5
  1. cpm: Counts per minute; SEM: Standard error from the mean; Mitogen: phytohemagglutinin (PHA); EGCG (50 μg/ml); IFN-γ: Interferon gamma; pg/ml: Picogram per ml. Her-2/neu and p53 (80 μg/ml). All results obtained by EGCG were significant at p < 0.01, as indicated by the symbol “§”.