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Table 1 The effect of epigallocatechin-3-gallate (EGCG) on breast cancer peripheral blood mononuclear cells (PBMC) proliferation and IFN-γ production

From: Analysis of the effect of the active compound of green tea (EGCG) on the proliferation of peripheral blood mononuclear cells

3H thymidine uptake by PBMC (cpm ± SEM)

Stimulation indices [SI] of PBMCs) (SI ± SEM)

IFN-γ release by PBMCs (pg/ml ± SEM)

Cell control

Mitogen alone

Mitogen + EGCG

Mitogen alone

Mitogen + EGCG

Cell control

Mitogen alone

Mitogen + EGCG

69 ± 7

11289 ± 1637

33 ± 4

172 ± 26

0.4 ± 0.04§

53 ± 8

2153 ± 454

38 ± 12§

Cell control

Anti-CD3 alone

Anti-CD3 + EGCG

Anti-CD3 alone

Anti-CD3 + EGCG

Cell control

Mitogen alone

Anti-CD3 + EGCG

199 ± 29

39252 ± 4182

73 ± 14

262 ± 49

1 ± 0.05

54 ± 42

24508 ± 717

10 ± 4

Cell control

Her-2/neu alone

Her-2/neu + EGCG

Her-2/neu alone

Her-2/neu + EGCG

Cell control

Her-2/neu alone

Her-2/neu + EGCG

101 ± 8

432 ± 79

40 ± 6

4.3 ± 0.7

0.4 ± 0.07

13 ± 6

62 ± 12

28 ± 9

Cell control

p53 alone

p53 + EGCG

p53 alone

p53 + EGCG

Cell control

p53 alone

p53 + EGCG

72 ± 9

972 ± 191

39 ± 5

9 ± 1

0.4 ± 0.06

52 ± 8

109 ± 11

33 ± 5

  1. cpm: Counts per minute; SEM: Standard error from the mean; Mitogen: phytohemagglutinin (PHA); EGCG (50 μg/ml); IFN-γ: Interferon gamma; pg/ml: Picogram per ml. Her-2/neu and p53 (80 μg/ml). All results obtained by EGCG were significant at p < 0.01, as indicated by the symbol “§”.