Evaluation of antimalarial activity of leaves of Acokanthera schimperi and Croton macrostachyus against Plasmodium berghei in Swiss albino mice

Table 8 Parasitaemia suppressive effect of aqueous extract of Acokanthera schimperi and mean survival time

Group	Dose (mg/kg)	Antimalarial activities on Day-4 post infection		Mean survival
Group	Dose (mg/kg)	% Parasitaemia ± SEM	% Suppression	Time in days
1	Distilled Water (1 mL)	52.80 ± 4.24	0.00	6.20 ± 0.20
2	200	41.0 ± 3.89	22.34	6.40 ± 0.25^b
3	400	40.80 ± 1.65	22.72	7.00 ± 0.77^b
4	600	39.80 ± 3.49	24.60	9.60 ± 0.51*
5	Chloroquine (25)	0.00	100.00	14.20 ± 0.58*

% parasitaemia and mean survival time results presented as mean ± SD; n = 5; values with Superscript b are not significantly different from the negative control (P > 0.05).* = there was a significant difference compared to negative controls (P < 0.05).

ISSN: 2662-7671