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Table 4 Effect of crude methanol and aqueous leaf extracts of Acokanthera schipmeri on body weight and PCV of P . berghei infected mice

From: Evaluation of antimalarial activity of leaves of Acokanthera schimperi and Croton macrostachyus against Plasmodium berghei in Swiss albino mice

Extracts/Treatments

Dose (mg/kg)

PCV

 

Body weight in grams

 

Day 0

Day 4

Day 0

Day 4

Methanol extracts

200

55.80 ± 0.37

49.20 ± 2.71*

29.20 ± 1.22

29.08 ± 1.09*

 

400

53.60 ± 0.40

52.80 ± 1.50*

31.82 ± 2.036

31.34 ± 2.34*

 

600

55.20 ± 0.37

46.20 ± 3.39*

29.98 ± 1.63

29.88 ± 0.89*

Distilled water

1 mL

55.20 ± 1.11

37.00 ± 2.94a

29.64 ± 1.99

26.96 ± 2.26*

Chloroquine

25

54.00 ± 1.14

55.60 ± 1.50*

28.20 ± 1.79

28.68 ± 2.10*

Aqueous extracts

200

53.60 ± 1.50

49.20 ± 1.80*

28.80 ± 1.53

28.90 ± 1.55*

 

400

54.00 ± 1.14

48.60 ± 1.69*

29.78 ± 2.08

28.14 ± 1.61*

 

600

52.20 ± 1.24

45.20 ± 2.92*

30.24 ± 1.48

28.52 ± 1.48*

Distilled water

1 mL

55.20 ± 1.11

37.00 ± 2.94a

29.72 ± 1.95

26.90 ± 2.28*

Chloroquine

25

54.00 ± 1.14

55.60 ± 1.50*

28.20 ± 1.79

28.68 ± 2.10*

  1. Results presented as mean ± SD; n = 5;* = there was no significant difference between Day-0 and Day-4 (P > 0.05); a = there was a significant difference between Day-0 and Day-4 (P < 0.05).