Evaluation of antimalarial activity of leaves of Acokanthera schimperi and Croton macrostachyus against Plasmodium berghei in Swiss albino mice

Table 3 Effect of crude methanol and aqueous extracts of Croton macrostachyus on body weight and PCV of P . berghei infected mice

Extract/Treatments	Doses (mg/kg)	PCV		Body weight in grams
Extract/Treatments	Doses (mg/kg)	Day0	Day4	Day0	Day4
Methanol extracts	200	54.60 ± 0.51	45.60 ± 1.17 ^a	30.06 ± 0.50	30.06 ± 0.61*
	400	55.70 ± 0.30	46.00 ± 2.98 ^a	29.68 ± 0.51	28.68 ± 0.10*
	600	54.68 ± 0.63	46.00 ± 1.30 ^a	30.60 ± 1.55	30.04 ± 1.43*
Distilled water	1 mL	55.00 ± 0.84	44.00 ± 1.80 ^a	28.78 ± 1.10	28.18 ± 1.07*
Chloroquine	25	53.20 ± 1.59	49.00 ± 1.09^*	29.96 ± 0.62	29.80 ± 0.66^*
Aqueous extracts	200	55.60 ± 0.24	43.20 ± 3.18 ^a	30.20 ± 1.75	28.18 ± 1.07*
	400	55.60 ± 0.24	45.60 ± 1.36 ^a	28.32 ± 1.60	28.66 ± 2.26*
	600	55.60 ± 0.24	45.00 ± 1.92 ^a	29.00 ± 0.95	28.48 ± 1.65*
Distilled water	1 mL	55.00 ± 0.84	44.00 ± 1.80 ^a	28.78 ± 1.10	28.18 ± 1.07*
Chloroquine	25	53.20 ± 1.59	49.00 ± 1.09*	29.96 ± 0.62	29.80 ± 0.66 ^*

Results presented as mean ± SD; n = 5; * = there was no significant difference, between Day-0 and Day-4 (P > 0.05); a = there was a significant difference between Day-0 and Day-4 (P < 0.05).

ISSN: 2662-7671