Table 2 Sub-acute toxicity effects of methanol and aqueous extracts of Acokanthera schimperi
Extract | Dose | Parameters | Day 0 | Day 4 | P-Value |
|---|---|---|---|---|---|
Methanol | 500 mg | Body weight (gm) | 31.74 ± 2.16 | 33.76 ± 2.08 | 0.162 |
PCV (%) | 54.60 ± 0.75 | 52.80 ± 1.50 | 0.195 | ||
WBC | not determined | not determined | |||
Hb (g/dL) | 16.36 ± 0.55 | 15.38 ± 0.43 | 0.052 | ||
750 mg | Body weight (gm) | 30.38 ± 0.59 | 31.68 ± 0.84 | 0.094 | |
PCV (%) | 55.40 ± 0.40 | 50.20 ± 2.18 | 0.057 | ||
WBC | not determined | not determined | |||
Hb (g/dL) | 17.10 ± 0.32 | 16.32 ± 0.63 | 0.074 | ||
1000 mg | Body weight (gm) | 32.22 ± .1.54 | 31.70 ± 1.72 | 0.073 | |
PCV (%) | 52.40 ± 0.75 | 49.80 ± 2.04 | 0.395 | ||
WBC | not determined | not determined | |||
Hb (g/dL) | 16.46 ± 0.27 | 14.68 ± 0.63 | 0.109 | ||
NC | Body weight (gm) | 29.04 ± 1.82 | 30.80 ± 1.59 | 0.078 | |
PCV (%) | 52.40 ± 0.98 | 51.20 ± 1.07 | 0.109 | ||
WBC | not determined | not determined | |||
Hb (g/dL) | 16.58 ± 0.79 | 15.48 ± 0.65 | 0.097 | ||
Aqueous | 500 mg | Body weight (gm) | 30.42 ± 1.45 | 31.52 ± 1.30 | 0.327 |
PCV (%) | 53.30 ± 1.41 | 50.20 ± 0.66 | 0.156 | ||
WBC | not determined | not determined | |||
Hb (g/dL) | 16.66 ± 0.38 | 14.86 ± 0.35 | 0.052 | ||
750 mg | Body weight (gm) | 31.34 ± 2.34 | 31.88 ± 2.11 | 0.573 | |
PCV (%) | 53.10 ± 1.33 | 49.40 ± 1.25 | 0.083 | ||
WBC | not determined | not determined | |||
Hb (g/dL) | 16.30 ± 0.72 | 14.96 ± 0.77 | 0.123 | ||
1000 mg | Body weight (gm) | 31.60 ± 2.36 | 32.90 ± 2.21 | 0.147 | |
PCV (%) | 54.48 ± 0.96 | 51.20 ± 2.15 | 0.227 | ||
WBC | not determined | not determined | |||
Hb (g/dL) | 17.10 ± 0.51 | 15.54 ± 0.43 | 0.123 | ||
NC | Body weight (gm) | 29.04 ± 1.82 | 30.80 ± 1.59 | 0.078 | |
WBC | not determined | not determined | |||
PCV (%) | 52.40 ± 0.98 | 51.20 ± 1.07 | 0.109 | ||
Hb (g/dL) | 16.58 ± 0.79 | 15.48 ± 0.65 | 0.097 |