Figure 1

Effects of AST on EAE progression and body weight in mice. A) Comparison of mean clinical scores after EAE induction. AST was administered at three different dosages (H: 50 mg/kg/day, M: 25 mg/kg/day, L: 10 mg/kg/day) i.p. from the day before MOG_35–55 immunization and lasted for 14 days as well as ASI (10 mg/kg/day). Methylprednisolone (MPD) served as positive control drug was given at 50 mg/kg/day i.p. from the day 8 to day 10 post-immunization. B) Change of body weight among different group mice. All data are presented as mean±standard error of mean (n = 14). ^**p < 0.01; ^***p < 0.001 vs EAE group.