Anti-hyperglycemic activity of Centella asiatica is partly mediated by carbohydrase inhibition and glucose-fiber binding

Table 2 Retarding effect of insoluble fibre of CA on the glucose movement (glucose dialysis retardation index)

Treatment	Dialysis for 30 min		Dialysis for 60 min
Treatment	Glucose in Dialysate(mmol/L)	Glucose dialysis retardation index (%)	Glucose in Dialysate(mmol/L)	Glucose dialysis retardation index (%)
CA 250 mg	0.83 ± 0.19	30.25	1.15 ± 0.15	32.75
CA 500 mg	0.76 ± 0.12	35.29	1.09 ± 0.06	36.26
CA 1000 mg	0.65 ± 0.09*	45.38	0.88 ± 0.12*	48.54
CMC 1000 mg	0.62 ± 0.11*	42.86	0.83 ± 0.07*	51.46
Control	1.19 ± 0.21	0	1.71 ± 0.14	0

Data are presented as Mean ± SEM (n = 7). Glucose dialysis retardation index = control (100%) – fibre (% of control value). Mean values marked with an asterisk (*) were significantly different from those of respective control groups (p < 0.05) (derived from repeated-measures ANOVA and adjusted using Bonferroni correction).

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