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Figure 5 | BMC Complementary and Alternative Medicine

Figure 5

From: Cephalotaxus griffithii Hook.f. needle extract induces cell cycle arrest, apoptosis and suppression of hTERT and hTR expression on human breast cancer cells

Figure 5

CGN PE extract induced cellular death is dependent on p53 expression in human breast cancer cells. ZR751 cells were transfected with TP53 siRNA for 24 h. After transfection, cells were exposed to different concentrations of PE extract for 24 h prior to analysis of (A) p53 expression by western blot or (B) cell viability by MTT assay. Each bar represents the mean ± SD (n = 3). Data denoted *(P < 0.05), **(P < 0.01), ***(P < 0.001) and ****(P < 0.0001) are significantly different compared to PE extract treatment alone (without TP53 siRNA treatment) between the same treatment concentration analysed by t-test.

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